FOXO3 Polyclonal Antibody
产品名称： FOXO3 Polyclonal Antibody
英文名称： FOXO3 Polyclonal Antibody
产品编号： K001577P
产品价格： null
产品产地： 北京市通州区马驹桥
品牌商标： solarbio
更新时间： 2025-01-02T09:53:49
使用范围：
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
- 邮编 : 101102
- 所在区域 : 北京
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Anti-FOXO3 Polyclonal Antibody 
品牌：solarbio | 货号：K001577P
英文名称 Anti-FOXO3 Polyclonal Antibody 宿主 Rabbit 别名 1110048B16Rik;2010203A17Rik;C76856;FKHRL1;Fkhr2;Foxo3a 应用 WB IHC IF 稀释比例 WB 1:500-2000. IHC 1:50-200. IF 1:50-200. 交叉反应 Human Mouse Rat 蛋白分子量 90kDa Gene ID 56484 保存 Store at -20°C. Avoid freeze / thaw cycles. 储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. 纯化方法 Affinity purification 亚型 IgG 免疫原 Recombinant protein of mouse FOXO3 性状 液体 Public
Immunogen
Range Recombinant protein of mouse FOXO3 Subcellular
Locations Cytoplasm Membrane Nucleus Swiss Prot Q9WVH4 克隆类型 Polyclonal Antibody 背景资料 Forkhead box O-class (FOXO) transcription factors are
mammalian homologue of DAF-16, a known lifespan
regulator of Caenorhabditis elegans. FOXO transcription
factors, such as FOXO1, FOXO3a, and FOXO4, have been
linked to the regulation of cell cycle, apoptosis, DNA
repair, oxidative stress, and metabolism. FOXO proteins
are proposed to be dual regulated by Akt-mediated
phosphorylation and Skp2-mediated ubiquitination,
which are usually initiated by growth factors and
cytokines. FOXO proteins are also activated by stress,
which induces gene expression that contributes to cell
cycle arrest, implicating FOXO proteins as tumor
suppressors. Specifically, FOXO3a (FKHR-L1) is a
transcriptional activator for apoptosis in the
absence of survival factors, such as in neural cell death
triggered by oxidative stress. In the presence of survival
factors like IGF-1, AKT1/PKB phosphorylates on Thr-32
and Ser-253. FOXO3a is inactivated when
phosphorylated by AKT1 on Thr-32 and Ser-253.
| 英文名称 | Anti-FOXO3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | 1110048B16Rik;2010203A17Rik;C76856;FKHRL1;Fkhr2;Foxo3a |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 90kDa |
| Gene ID | 56484 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of mouse FOXO3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of mouse FOXO3 |
| Subcellular Locations | Cytoplasm Membrane Nucleus |
| Swiss Prot | Q9WVH4 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Forkhead box O-class (FOXO) transcription factors are mammalian homologue of DAF-16, a known lifespan regulator of Caenorhabditis elegans. FOXO transcription factors, such as FOXO1, FOXO3a, and FOXO4, have been linked to the regulation of cell cycle, apoptosis, DNA repair, oxidative stress, and metabolism. FOXO proteins are proposed to be dual regulated by Akt-mediated phosphorylation and Skp2-mediated ubiquitination, which are usually initiated by growth factors and cytokines. FOXO proteins are also activated by stress, which induces gene expression that contributes to cell cycle arrest, implicating FOXO proteins as tumor suppressors. Specifically, FOXO3a (FKHR-L1) is a transcriptional activator for apoptosis in the absence of survival factors, such as in neural cell death triggered by oxidative stress. In the presence of survival factors like IGF-1, AKT1/PKB phosphorylates on Thr-32 and Ser-253. FOXO3a is inactivated when phosphorylated by AKT1 on Thr-32 and Ser-253. |